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MedicationsZepbound® Vial
Tirzepatide · FDA-approved

Zepbound® Vial

The same FDA-approved tirzepatide as the KwikPen, in a vial format- often more accessible through the Lilly Direct single-dose vial program. Easier to access due to lower cost.

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Once weekly Injectable
Zepbound® Vial Important Safety Information
Active ingredient
Tirzepatide
How often
Once weekly
Form
Single-dose vial
Avg. weight loss in trials
~21%
How it works

How Zepbound vial helps you lose weight

The vial contains the same FDA-approved tirzepatide as the KwikPen, with the same dual GIP/GLP-1 action and the same results, in a single-dose vial format that is often easier to obtain.

How to take it

Once weekly, Single-dose vial

Draw up and inject once a week with a syringe, on the same day each week. Your care team will walk you through it.

Your physician will start you on a low dose and adjust it monthly based on how you respond. Always follow the instructions provided with your prescription.

Getting started with Zepbound vial

Step 1

Complete your intake

Answer a health questionnaire covering your medical history, current medications, and goals from any device.

Step 2

Physician review

A board-certified physician licensed in Michigan or Ohio evaluates whether Zepbound vial is right for you.

Step 3

Prescription sent

If appropriate, your prescription goes to LillyDirect, which contacts you to arrange payment and ships to your door.

Step 4

Ongoing support

Monthly follow-ups, messaging, and video or phone visits as your physician adjusts your dose.

How Zepbound vial compares

Read: Zepbound vs. Wegovy →
Wegovy® Pen
Semaglutide
Wegovy® Pill
Semaglutide
Zepbound® KwikPen®
Tirzepatide
Zepbound® Vial
Viewing
Foundayo™ Pill
Orforglipron
Active ingredient
Wegovy® Pen: Semaglutide
Wegovy® Pill: Semaglutide
Zepbound® KwikPen®: Tirzepatide
Zepbound® Vial: Tirzepatide
Foundayo™ Pill: Orforglipron
Form
Wegovy® Pen: and how to use the pen
Wegovy® Pill: Tablet
Zepbound® KwikPen®: Multi-dose pen
Zepbound® Vial: Single-dose vial
Foundayo™ Pill: Tablet
How often
Wegovy® Pen: Wegovy dosing schedule
Wegovy® Pill: Once daily
Zepbound® KwikPen®: Once weekly
Zepbound® Vial: Once weekly
Foundayo™ Pill: Once daily
Avg. weight loss in trials
Wegovy® Pen: ~15%
Wegovy® Pill: ~14%
Zepbound® KwikPen®: ~21%
Zepbound® Vial: ~21%
Foundayo™ Pill: ~12%
Pharmacy program
Wegovy® Pen: NovoCare
Wegovy® Pill: NovoCare
Zepbound® KwikPen®: LillyDirect
Zepbound® Vial: LillyDirect
Foundayo™ Pill: LillyDirect

Average body weight reduction reported in each medication's key clinical trial at the highest studied dose; individual results vary. See medication pricing.

Important Safety Information

Zepbound® Vial (tirzepatide)
Warning: risk of thyroid C-cell tumors

GLP-1 medications may cause tumors in the thyroid, including thyroid cancer. In studies with rodents, these medicines caused thyroid tumors, including thyroid cancer. It is not known if they cause thyroid tumors or medullary thyroid carcinoma (MTC) in people. Do not use if you or any of your family have ever had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.

Who should not use it

Do not use if you have had a serious allergic reaction to the active ingredient or any of the ingredients in the medication.

Most common side effects

Nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, headache, fatigue, dizziness, bloating, belching, and heartburn. These are most common when starting or increasing a dose and often improve over time.

Pregnancy & birth control

Tell your provider if you are pregnant, plan to become pregnant, or are breastfeeding. Some medications in this class may reduce the effectiveness of birth control pills taken by mouth.

Possible serious side effects

Inflammation of the pancreas (pancreatitis): severe stomach pain that will not go away, with or without vomiting
Gallbladder problems, including gallstones
Low blood sugar, especially if you also use insulin or a sulfonylurea
Kidney problems, which may be worsened by dehydration from nausea, vomiting, or diarrhea
Serious allergic reactions
Increased heart rate
Changes in vision in people with type 2 diabetes
Depression or thoughts of suicide
Food or liquid getting into the lungs during surgery or procedures that use anesthesia or deep sedation

This summary does not include all information about Zepbound® Vial. Read the full Prescribing Information and Medication Guide, and talk with your Cabot physician about your medical conditions and all medications you take. Call 911 for a medical emergency.

Other FDA-approved options

Semaglutide
Wegovy® Pen
Wegovy dosing schedule · Injectable
Semaglutide
Wegovy® Pill
Once daily · Oral
Tirzepatide
Zepbound® KwikPen®
Once weekly · Injectable
Orforglipron
Foundayo™ Pill
Once daily · Oral